It's hard to beat the polished and newly free FeedDemon when it comes to desktop news-reader features. And you can sync it with the Newsgator site to stay on top of news even when you're out and about.
Some nice interface touches, such as attractive colored tabs and panels that keep their names when they collapse, make RSS Bandit a useful tool for keeping up with the news.
In Feedreader you can create custom Smartfeeds that pull together news posts from all of your subscribed feeds matching one or more e-mail-like filtering rules. For instance, you can capture all posts that contain "Apple" or "MacOS" in the title or body.
Awasu Personal Edition
This program offers you several nice features, such as a quick full-screen switch for easy news reading on your desktop. The free personal edition, however, updates the content only once an hour.
Six different feed presentation styles, including Essay, Newspaper, and Firefox Sage, make this news reader (in beta) worth checking out.
Bring the RSS love to your BlackBerry, J2ME, Nokia, Palm OS, or Windows Mobile smart phone with this mobile news reader. The free version is limited to ten news feeds and relies on your phone's data connection.
A simple and straightforward desktop-app-like reader in a Web browser, Feedshow can switch between resizable two- and three-panel layouts and accepts keyboard shortcuts. And you don't have to download anything to your computer.
This Firefox add-on for serious news junkies scrolls updates for your Live Bookmark feed subscriptions across the top or bottom of the browser window. Mouse over a headline for a summary, and click it to bring up the whole article in the browser.