The LaCie d2 Safe ($350 for 1TB) was third among eight encrypted portable drives that we recently looked at.
This hefty drive features a fingerprint reader and can connect to your computer over FireWire 400 and 800 in addition to USB 2.0. I found LaCie's software setup more time-consuming than some others, but it has an obvious benefit: LaCie's built-in fingerprint software allows you to plug the drive into either a Mac OS system or a Windows box and to work in the encrypted partition. The drive also features the sturdiest housing I've seen, plus a Kensington lock port so you can secure it to a desk.
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