ToniArts' repair tool searches your Registry for unnecessary entries and gives you the option to delete them. You can tell it to skip entries containing a specific word, and print or save your results.
EasyCleaner has other tricks, as well. It has an Add/remove programs tool (although that's no better than Windows's), tools to find duplicate and unnecessary files, a space usage tool that tells you where your hard drive space is going, and a Startup inspector that could take the place of msconfig.
And it has an undo. Should you regret a particular Registry change, you can unto them all or just the one.
Note: Deleting entries from the Registry can be dangerous, so it is wise to make a backup of your Registry before deleting any settings.