Note: This review addresses v.46 of the software.
If you're looking for a graphics program that lets you create illustrations and graphics, much like Freehand or Illustrator, then give Inkscape a whirl.
It includes a surprisingly powerful set of tools for creating graphics from scratch, or for editing existing graphics or photographs. You'll find numerous drawing tools, the ability to create layers and combine them, and more.
The program supports the standard Scalable Vector Graphics (SVG) file format, as well as many others. It imports files from many formats, including .jpg, .png, .tif and others, and exports to numerous vector-based formats and .png.
Note: This program is donationware. It is free to use, but the author accepts and encourages donations towards further development.