Vista Manager 64-bit
If you want to tweak Windows Vista six ways to Sunday, you should give Vista Manager a try. This remarkable program packs numerous utilities--each one of which lets you change multiple Vista settings--into a single interface.
Listing all the tweaks and customizations you can do with this program would practically fill a book, so I won't try to detail them all. But if you'd like to turn Aero on or off, disable specific Aero features, or even force Aero to work on an older PC, you can from here. Vista Manager also lets you customize just about every part of the Desktop, Start menu, and Taskbar, as well as your icons.
Then there's a whole set of optimization tweaks for speeding up your system, plus system repair tools, ways to tweak Internet Explorer, security enhancements, network customization tools...Suffice it to say, the list is long indeed. There's even a Registry defragmenter and cleaner.
Note: This software comes in 32-bit and 64-bit versions. This is the 64-bit version, which is for 64-bit PCs running a 64-bit OS. If your PC is running a different supported OS, please download the 32-bit version instead.