Such accidents are eliminated with SharpKeys, a free, little one-trick pony as obscure as Sasquatch. SharpKeys allows you to move your keys around to suit your idea of how a keyboard should be laid out. For example, I've banished my Caps Lock key to the Scroll Lock key, which had its hey-day when Lotus 1-2-3 was hot. My Caps Lock now functions as another Delete key. The arrangement lets me select files by mousing with my right hand and zapping them with my left.
You can come up with your own scheme using any of the keys, including those that most macro programs won't change. Well, almost any key. Some boards with keys devoted to gaming may elude SharpKeys, but it does work with multimedia keys. And it does all this by creating some Registry entries rather than lurking in the background all the time soaking up memory.