MoinMoin is a powerful open source wiki with an optional desktop mode.
Zbar is a free, tiny, portable tool that puts a taskbar on your secondary monitor, and lets you pick different wallpapers for every monitor.
Free utility MultiMon Taskbar Free adds a simple taskbar to your secondary monitor...but even at that price, it may not be the best solution.
CorelDRAW Graphics Suite X6 is a powerful graphics suite, and a worthy opponent for Adobe Illustrator and InDesign.
Privoxy is a free, open-source local proxy for blocking ads and tracking scripts.
Screenshot Captor offers powerful image capture tools, outperforming Snagit in some cases.
Process Explorer is a super-powerful, free alternative to Task Manager, from Microsoft.
KeyTweak lets you remap keyboard keys system-wide.
TiddlyWiki is a free, portable Wiki that runs in any modern Web browser.
Toggl is a simple, cross-platform time tracking solution for individuals and groups.
Zim is a fast, free, and easy desktop wiki application for managing information.
Goalscape Desktop offers a unique and visual way to realize your goals and make dreams a reality.
VueMinder Pro is a powerful desktop calendar with online sync capabilities.
Wikispaces lets you set up a powerful multi-user personal wiki with simple editing capabilities for free.
Springpad is a free service for saving and categorizing information, with rich parsing abilities.